Recombinant Human Biglycan protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Biglycan protein Leu17-Lys368 (Accession# P21810) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 633 |
| 蛋白编号 | P21810 |
| 预测分子量 | 65.8 kDa |
| SDS-PAGE | 68-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Biglycan is a member of the small leucine-rich proteoglycan (SLRP) family. It consists of a core protein of 42 kDa containing leucine-rich repeats (LRRs), to which two chondroitin/dermatan sulfate side chains are covalently bound. The tissue-specific chondroitin- or dermatan-sulfate glycosaminoglycan chains of biglycan are attached to amino acid residues at the N-terminus of the core protein. Biglycan is a ubiquitous component of the connective tissue matrix and may act as a signaling molecule. Upregulation of biglycan has been reported in multiple types of solid cancer.
参考文献:
1.Schaefer L. et al. (2008). J Biol Chem. 283(31):21305-21309. 2.Bianco P. et al. (1990). J Histochem Cytochem. 38(11):1549-1563. 3.Iozzo RV. (1999). J Biol Chem. 274(27):18843-18846. 4.Nastase MV. et al. (2012). J Histochem Cytochem. 60(12):963-975. 5.Zhao SF. et al. (2020). Oncol Lett. 19(3):1673-1682.
