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验证数据展示

  • WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 84655-5-RR (same clone as 84655-5-PBS)

    IHC staining of mouse liver using 84655-5-RR (same clone as 84655-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 84655-5-RR (CXCR3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • WB analysis of rat liver using 84655-5-RR (same clone as 84655-5-PBS)

    WB analysis of rat liver using 84655-5-RR (same clone as 84655-5-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84655-5-RR

    Affinity and Kinetic Characterization of 84655-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84655-5-RR against Human CXCR3 were performed. The affinity constant is 1.84 nM.

CXCR3 Recombinant monoclonal antibody, PBS Only

CXCR3 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84655-5-PBS

产品说明书

CloneNo. 241790E9

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

CMKAR3, CKR-L2, CKR L2, CD183, CD182

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84655-5-PBS targets CXCR3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Recombinant protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 chemokine (C-X-C motif) receptor 3
别名 CMKAR3, CKR-L2, CKR L2, CD183, CD182
计算分子量 368 aa, 41 kDa
观测分子量45 kDa
GenBank蛋白编号BC034403
基因名称 CXCR3
Gene ID (NCBI) 2833
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP49682
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of several cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. The binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively, spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as a functional receptor for CXCL4 (PMID:12782716).

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