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验证数据展示

  • WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 84655-5-RR (same clone as 84655-5-PBS)

    IHC staining of mouse liver using 84655-5-RR (same clone as 84655-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 84655-5-RR (CXCR3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • WB analysis of rat liver using 84655-5-RR (same clone as 84655-5-PBS)

    WB analysis of rat liver using 84655-5-RR (same clone as 84655-5-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84655-5-RR

    Affinity and Kinetic Characterization of 84655-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84655-5-RR against Human CXCR3 were performed. The affinity constant is 1.84 nM.

CXCR3 Recombinant monoclonal antibody, PBS Only

CXCR3 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84655-5-PBS

产品说明书

CloneNo. 241790E9

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

241790E9, CD182, CD183, CKR L2, CKR-L2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84655-5-PBS targets CXCR3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg2269

Product name: Recombinant Human CXCR3 protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 1-53 aa of BC034403

Sequence: MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 chemokine (C-X-C motif) receptor 3
别名 241790E9, CD182, CD183, CKR L2, CKR-L2
计算分子量 368 aa, 41 kDa
观测分子量45 kDa
GenBank蛋白编号BC034403
基因名称 CXCR3
Gene ID (NCBI) 2833
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP49682
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of several cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. The binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively, spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as a functional receptor for CXCL4 (PMID:12782716).

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