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验证数据展示

  • WB analysis of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    WB analysis of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    mouse spleen tissue was subjected to SDS PAGE followed by western blot with 84166-5-RR (CD6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84166-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    IHC staining of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 84166-5-RR (CD6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84166-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    IHC staining of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 84166-5-RR (CD6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84166-5-PBS in a different storage buffer formulation.

  • IF Staining of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    IF Staining of mouse spleen using 84166-5-RR (same clone as 84166-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse spleen tissue using CD6 antibody (84166-5-RR, Clone: 241471H6 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84166-5-PBS in a different storage buffer formulation.

Mouse CD6 Recombinant monoclonal antibody, PBS Only

CD6 Uni-rAb® Recombinant Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 84166-5-PBS

产品说明书

CloneNo. 241471H6

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

WB, IHC, IF-P, Indirect ELISA

别名

241471H6, T-cell differentiation antigen CD6

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84166-5-PBS targets CD6 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with mouse samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 mouse
免疫原

CatNo: Eg1401

Product name: Recombinant Mouse CD6 protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 17-396 aa of NM_009852.3

Sequence: GLPSPAPSGQHKNGTIPNMTLDLEERLGIRLVNGSSRCSGSVKVLLESWEPVCAAHWNRAATEAVCKALNCGDSGKVTYLMPPTSELPPGATSGNTSSAGNTTWARAPTERCRGANWQFCKVQDQECSSDRRLVWVTCAENQAVRLVDGSSRCAGRVEMLEHGEWGTVCDDTWDLQDAHVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGIDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCRSLGCGSAVARPRGLPHSLDGRMYYSCKGQEPALSTCSWRFNNSNLCSQSRAARVVCSGSQRHLNLSTSEVPSRVPVTIESSVPVSVKDKDSQG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD6 antigen
别名 241471H6, T-cell differentiation antigen CD6
计算分子量72kDa
观测分子量130 kDa
GenBank蛋白编号NM_009852.3
基因名称 Cd6
Gene ID (NCBI) 12511
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ61003-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD6 is a type I transmembrane glycoprotein of 105-130 kDa that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harbouring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.

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