验证数据展示
发表文章中的应用
| WB | See 5 publications below |
产品信息
10459-1-AP targets Caspase 7/p20/p11 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, bovine |
| 免疫原 | Caspase 7/p20/p11 fusion protein Ag0670 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | caspase 7, apoptosis-related cysteine peptidase |
| 别名 | Apoptotic protease Mch 3, CASP 7, CASP7, Caspase 7, Caspase 7/p20/p11, Caspase7, CMH 1, ICE LAP3, ICE like apoptotic protease 3, MCH3 |
| 计算分子量 | 303 aa, 34 kDa |
| GenBank蛋白编号 | BC015799 |
| 基因名称 | Caspase 7 |
| Gene ID (NCBI) | 840 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P55210 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Caspase 7(CASP7), like caspases 3 and 6, contains a short prodomain and, upon apoptotic induction, the 35 kDa proform is converted into a 32 kDa intermediate or preactive form which is further processed into two active subunits consisting of the p20 or large (18 kDa) subunit and the p10 or small (11 kDa) subunit and it is present in the brain, which is up-regulated and activated after traumatic injury(PMID:15953353). Caspase-7 is classified as a member of the subgroup of cysteine proteases most related to the Caenorhabditis elegans factor CED-3, which also includes caspase-3, -6, and -9(PMID:9426061). The protein is involved in the activation cascade of caspases responsible for apoptosis execution.
发表文章
| Species | Application | Title |
|---|---|---|
Ann Transl Med Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma | ||
J Pharm Pharmacol Maackiain suppresses the development of cervical cancer via AMPK priming autophagy | ||
J Bone Oncol Mometasone furoate inhibits tumor progression and promotes apoptosis through activation of the AMPK/mTOR signaling pathway in osteosarcoma | ||
Biomolecules Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model | ||
Phytother Res Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation |