Recombinant Mouse Chromogranin A protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Chromogranin A protein Leu19-Gly463 (Accession# P26339) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 12652 |
| 蛋白编号 | P26339 |
| 预测分子量 | 75.5 kDa |
| SDS-PAGE | 70-78 kDa and 85-110 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells, which is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A is one of the most used tumor markers in NET's (neuroendocrine tumors).
参考文献:
1. Modlin, Irvin M et al. Annals of surgical oncology vol. 17,9 (2010): 2427-43. 2. Louthan, O. Folia biologica vol. 57,5 (2011): 173-81. 3. Nobels, F R et al. European journal of clinical investigation vol. 28,6 (1998): 431-40. 4. Campana, Davide et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology vol. 25,15 (2007): 1967-73.
