Recombinant Rat CD25/IL-2R alpha protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | CHO-derived Rat CD25 protein Glu22-Gln235 (Accession# P26897) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 25704 |
| 蛋白编号 | P26897 |
| 预测分子量 | 50.5 kDa |
| SDS-PAGE | 58-65 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD25, also known as the Interleukin-2 Receptor alpha chain (IL-2Rα), is a critical surface glycoprotein that defines a key functional state in immune cells. Proliferation of T lymphocytes is triggered by the interaction of IL-2 with its specific receptor following T lymphocyte activation. The receptor for IL-2 has three forms, generated by different combinations of three different proteins, the alpha chain (IL-2R alpha), the beta chain (IL-2R beta), and the gamma chain (IL-2R gamma) (PMID: 8476561). IL-2R alpha (also known as CD25) is present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes. CD25 is also found on natural CD4+ Foxp3+ Treg cells (PMID: 22585674).
参考文献:
1. Minami, Y et al. Annual review of immunology vol. 11 (1993): 245-68. 2. Triplett, Todd A et al. European journal of immunology vol. 42,7 (2012): 1893-905.
