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Recombinant Human VEGF121 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1263

Print datasheet

Synonyms

VEGF, VEGFA, L-VEGF, N-VEGF, Vascular Endothelial Growth Factor

验证数据展示

  • Purity of Recombinant Human VEGF121 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human VEGF121 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <1.0 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human VEGF121 protein Ala27-Arg147 (Accession# P15692-9) with a His tag at the C-terminus.
基因ID 7422
蛋白编号 P15692-9
预测分子量 15.1 kDa
SDS-PAGE
组分 Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

VEGFA, also named VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are associated with microvascular complications of diabetes type 1 (MVCD1).

参考文献:

1. Apte, Rajendra S et al. Cell vol. 176,6 (2019): 1248-1264.
2. Carmeliet, P et al. Nature vol. 380,6573 (1996): 435-9.
3. Pérez-Gutiérrez, Lorena, and Napoleone Ferrara. Nature reviews. Molecular cell biology vol. 24,11 (2023): 816-834.