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Recombinant Human FGFR3 (IIIb) protein (hFc Tag, Myc Tag, His Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

hFc Tag, Myc Tag, His Tag

生物活性

EC50: 95-380 ng/mL

Cat no : Eg0194

Print datasheet

Synonyms

FGFR3, ACH, CD333, CEK2, FGFR 3

验证数据展示

  • Purity of Recombinant Human FGFR3 (IIIb) was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human FGFR3 (IIIb) was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • Immobilized Human FGF basic (His tag) at 1 μg/mL (100 μL/well) can bind Human FGFR3 (IIIb) (hFc tag, Myc tag, His tag) with a linear range of 95-380 ng/mL.

    Immobilized Human FGF basic (His tag) at 1 μg/mL (100 μL/well) can bind Human FGFR3 (IIIb) (hFc tag, Myc tag, His tag) with a linear range of 95-380 ng/mL.

  • The purity of Human FGFR3 (IIIb) was greater than 90% as determined by SEC-HPLC.

    The purity of Human FGFR3 (IIIb) was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Immobilized Human FGF basic (His tag) at 1 μg/mL (100 μL/well) can bind Human FGFR3 (IIIb) (hFc tag, Myc tag, His tag) with a linear range of 95-380 ng/mL.
来源 HEK293-derived Human FGFR3 (IIIb) protein Glu23-Gly377 (Accession# P22607-2) with a human IgG1 Fc tag, a Myc tag and a His tag at the C-terminus.
基因ID 2261
蛋白编号 P22607-2
预测分子量 67.1 kDa
SDS-PAGE 85-100 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

FGFR3 (Fibroblast growth factor receptor 3) is a tyrosine-protein kinase that that acts as cell-surface receptor for fibroblast growth factors. FGFR3 binds acidic and basic fibroblast GH and plays important roles in development, osteogenesis, and bone maintenance. FGFR3 is highly expressed in chondrocytes and osteoblasts, and germline mutations are associated with bone growth disorders such as achondroplasia, chondrodysplasia, and thanatophoric dysplasia. Due to frequent mutations in certain cancers, FGFR3 gene has also been associated with tumor progression.

参考文献:

1.Eswarakumar VP, et al. (2005). Cytokine Growth Factor Rev. 16(2):139-149.
2.Tiong KH, et al. (2013). Apoptosis. 18(12):1447-1468.
3.Kacew A, et al. (2020). Front Immunol. 11:575258.
4.Horton WA, et al. (2007). Lancet. 370(9582):162-172.
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