Recombinant Rat CD59 protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat CD59 protein Asn27-Asn101 (Accession# P27274) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 25407 |
| 蛋白编号 | P27274 |
| 预测分子量 | 34.7 kDa |
| SDS-PAGE | 35-45 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD59 is a glycosylphosphatidylinositol (GPI)-anchored cellular receptor that acts as a gatekeeper of protein pore formation. As an immune regulator, CD59 prevents pore formation by the complement membrane attack complex (MAC). It is the only membrane-bound inhibitor of the terminal pathway, abrogating membrane rupture by MAC and further polymerization of the pore. CD59 is widely distributed in normal tissues and cells, such as blood cells, heart, liver, spleen, kidney, endothelia, various epithelial cells, and skeletal muscles.
参考文献:
1. Kimberley FC. et al. (2007) Mol Immunol. 44(1-3):73-81. 2. Iwasa K. et al. (2022) Neurol Neuroimmunol Neuroinflamm. 10(1):e200057. 3. Voisin TB. et al. (2023) Toxins (Basel). 15(7):430. 4. Couves EC. et al. (2023) Nat Commun. 14(1):890.
