Recombinant Rat ACVR1 protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat ACVR1 protein Met21-Glu123 (Accession# P80201) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 79558 |
| 蛋白编号 | P80201 |
| 预测分子量 | 37.8 kDa |
| SDS-PAGE | 39-49 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Activin A receptor type I (ACVR1) is a transmembrane serine/threonine kinase and belongs to the transforming growth factor-β superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 plays an important role in hematopoiesis and anemia via the BMP6/ACVR1/SMADpathway, which regulates expression of hepcidin, the master regulator of iron homeostasis.
参考文献:
1.Valer JA. et al. (2019) Cells. 8(11):1366. 2.Nagar G. et al. (2023) Brief Funct Genomics. 22(2):123-142. 3.Duminuco A. et al. (2023) Cancers (Basel). 16(1):154.
