Recombinant mouse HE4/WFDC2 protein
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse HE4 protein Thr26-Phe174 (Accession# Q9DAU7) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 67701 |
| 蛋白编号 | Q9DAU7 |
| 预测分子量 | 42.1 kDa |
| SDS-PAGE | 50-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Wfdc2 (Whey Acidic Protein Four Disulfide Core Domain 2) is a protease inhibitor that is highly expressed in the lung and is enriched in the nasopharynx. It is the most highly expressed family member in differentiated epithelial cells isolated from the trachea, nasal passages, and middle ear. Wfdc2 consists of 5 exons with exon 3 encoding an unstructured linker region that separates the two WFDC domains. This genomic organization appears to be restricted to the Muridae and Cricetidae families of rodents. Similar to the situation in humans, mouse Wfdc2 can be alternatively spliced to yield a number of distinct transcripts that have the potential to generate a repertoire of distinct protein isoforms.
参考文献:
1. Jeong H, et al. (2021) Gastroenterology. 161(3):953-967.e15. 2. Zhang T, et al. (2020) Biochem Biophys Res Commun. 522(2):456-462. 3. Nakajima K, et al. (2019) Dis Model Mech. 12(11): dmm040139.
