Recombinant Mouse TNFSF12 protein (mFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse TNFSF12 protein Arg105-His249 (Accession# O54907) with a mouse IgG Fc tag at the N-terminus. |
| 基因ID | 21944 |
| 蛋白编号 | O54907 |
| 预测分子量 | 43.7 kDa |
| SDS-PAGE | 44-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
TNFSF12 (Tumor necrosis factor ligand superfamily member 12), also known as TWEAK (TNF-related weak inducer of apoptosis), belongs to the TNF superfamily and is expressed in a variety of tissues and by certain types of immune cells and cancer cell lines, which could activate the processing of initiator caspase-8 as well as caspase-9 and lead to the extrinsic and intrinsic apoptosis. co-culturing with alveolar macrophages or treating with TNFSF12 substantially enhanced fbroblast cell proliferation and resulted in increased expression of extracellular matrix (ECM) and fbrosis-related factors.
参考文献:
1. Chen J, et al. (2024). Am J Transl Res. Aug 15;16(8):4120-4133. 2. Guo L, et al. (2024). J Transl Med. Jul 29;22(1):698.
