Recombinant Mouse Antithrombin III protein (mFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Antithrombin III protein His33-Asn465 (Accession# P32261) with a mouse IgG Fc tag at the N-terminus. |
| 基因ID | 11905 |
| 蛋白编号 | P32261 |
| 预测分子量 | 76.6 kDa |
| SDS-PAGE | 75-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Serpin C1 is a plasma protease inhibitor belonging to the serpin superfamily. It plays a critical role in regulating the blood coagulation cascade and the complement system by inhibiting various activated serine proteases of the coagulation system, including thrombin. It is synthesized in the liver and secreted into the bloodstream, circulating as an inhibitor of serine proteases. Serpin C1 is the major control serpin of the kallikrein-kinin system (KKS), and its deficiency can lead to uncontrolled activation of KKS, resulting in the generation of the vasoactive peptide bradykinin, which is associated with hereditary angioedema (HAE).
参考文献:
1.Drouet C. et al. (2022). Front Allergy. 3:835503. 2.Ponard D. et al. (2020). Hum Mutat. 41(1):38-57.
