Recombinant Mouse Oncostatin M/OSM protein (mFc Tag)(HPLC verified)
种属
Mouse
纯度
>90 %, SDS-PAGE
>90%, SEC-HPLC
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE >90%, SEC-HPLC |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Oncostatin M protein Asn25-Arg206 (Accession# P53347) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 18413 |
| 蛋白编号 | P53347 |
| 预测分子量 | 47.2 kDa |
| SDS-PAGE | 50-65 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Osm (Oncostatin M) is structurally and functionally related to a family of cytokines that includes the leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), interleukin-11 (IL-11), cardiotrophin-1 (CT-1), and interleukin-6 (IL-6). Osm is produced primarily by various inflammatory cells, including neutrophils, eosinophils and macrophages, and plays an important role in the modulation of inflammatory responses. Treatment of mice with OSM induced the shift of cytokine production profiles from inflammatory to anti-inflammatory in the adipose tissue with the phenotypic change of ATMs from M1 type to M2 type.
参考文献:
1. Yoshimura A, et al. (1996). EMBO J. 15(5):1055-1063. 2. Lindberg, R. A, et al. (1998). Mol Cell Biol. vol. 18,6: 3357-67. 3. Komori T, et al. (2015). Diabetologia, 58(8), 1868–1876.
