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Recombinant Mouse Mup1 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3024

Print datasheet

Synonyms

Major urinary protein 1

验证数据展示

  • Purity of Recombinant Mouse Mup1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Mup1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse Mup1 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse Mup1 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Mup1 protein Glu19-Glu180 (Accession# P11588) with a rabbit IgG Fc tag at the C-terminus.
基因ID 17840
蛋白编号 P11588
预测分子量 44.7 kDa
SDS-PAGE 45-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Mup1, or major urinary protein 1, is a member of the lipocalin family and is abundantly secreted into the circulation by the liver. It binds to lipophilic pheromones and is excreted in urine, mediating chemical communication in rodents. Beyond its role in chemical signaling, Mup1 has been identified as a regulator of glucose and lipid metabolism. Mup1 expression is significantly reduced in genetic and dietary fat-induced obesity and diabetes. Mup1 has been shown to suppress hepatic gluconeogenesis and promote energy expenditure in skeletal muscle by stimulating mitochondrial biogenesis and function. In chronic alcohol-induced metabolic disorders, Mup1 mediates the alleviation of hepatic endoplasmic reticulum (ER) stress and insulin resistance.

参考文献:

1.Zhou Y. et al. (2009). J Biol Chem. 284(17):11152-11159.
2.Zhou Y. et al. (2010). Vitam Horm. 83:151-163.
3.Zhang H. et al. (2024). Gut Microbes. 16(1):2367342.
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