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Recombinant Mouse LY75/DEC-205 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2649

Print datasheet

Synonyms

CD205, DEC 205, DEC-205, Ly75, Ly-75

验证数据展示

  • Purity of Recombinant Mouse LY75 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse LY75 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

  • The purity of Mouse LY75/DEC-205 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse LY75/DEC-205 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse LY75 protein Ser28-Asp1667 (Accession# Q60767) with a rabbit IgG Fc tag at the C-terminus.
基因ID 17076
蛋白编号 Q60767
预测分子量 214.1 kDa
SDS-PAGE 200-300 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Ly75 (Lymphocyte Antigen 75), also known as DEC205/CD205, is a type I transmembrane protein belonging to the C-type lectin receptor family. Ly75 is expressed in immune cells and cancers, and participates in tumor immunity through a key role in endocytosis by major histocompatibility complex (MHC) molecules and in antigen presentation to T-cells. Ly75 can regulate EOC cell phenotype and transfer potential. 75 regulates EOC cell phenotype and metastatic potential and has a direct role in regulating Wnt/β-cyclin pathway activity in epithelial ovarian cancer (EOC) cells. (PMID: 32156068)

参考文献:

1. Mehdi S, et al. Int J Mol Sci. 2020;21(5):1848.                                                       
2. Mehdi S,et al. Int J Mol Sci. 2020;21(14):4992.                                                          
3. Gil M, et al. J Clin Med. 2020;9(5):1383.
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