Recombinant Mouse IL18BP protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IL18BP protein Thr29-Ala193 (Accession# Q9Z0M9) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 16068 |
| 蛋白编号 | Q9Z0M9 |
| 预测分子量 | 44.0 kDa |
| SDS-PAGE | 48-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL-18 Binding Protein (IL18BP) is a soluble protein that acts as a natural antagonist of interleukin-18 (IL-18), a pro-inflammatory cytokine involved in immune responses. It binds to IL-18 with high affinity, preventing IL-18 from interacting with its receptors (IL-18Rα and IL-18Rβ) and thus inhibiting its biological activity. This regulation is crucial for maintaining immune homeostasis and preventing excessive inflammation. IL18BP is a biomarker for disease activity and severity, as well as a therapeutic target in cancer immunotherapy.
参考文献:
1.Novick D. et al. (1999). Immunity. 10(1):127-136. 2.Kim SH. et al. (2000). Proc Natl Acad Sci U S A. 97(3):1190-1195. 3.Belkaya S. et al. (2019). J Exp Med. 216(8):1777-1790. 4.Zhou T. et al. (2020). Nature. 583(7817):609-614.
