Recombinant Mouse CD314/NKG2D protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD314 protein Phe90-Val232 (Accession# O54709-1) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 27007 |
| 蛋白编号 | O54709-1 |
| 预测分子量 | 43.6 kDa |
| SDS-PAGE | 45-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Natural killer group 2D (NKG2D) (CD314) is an activating receptor on NK cells, CD8+ T cells, NKT cells and γδ+ T cells. Interleukin (IL)-15-induced up-regulation of NKG2D on intraepithelial cytotoxic T cells (IELs) and NKG2D ligands on enterocytes is a hallmark in CD and is responsible for epithelial cell destruction and subsequent villous atrophy.
参考文献:
1. Guy-Grand D, et al. Eur J Immunol. 1996;26:2248–2256. 2. Abadie V, et al. Semin Immunopathol. 2012;34:551–566.
