Recombinant Human Tie1 protein (mFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Tie1 protein Ala22-Gln760 (Accession# P35590-1) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 7075 |
| 蛋白编号 | P35590-1 |
| 预测分子量 | 106.6 kDa |
| SDS-PAGE | 110-120 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Tyrosine-protein kinase receptor Tie-1 (Tie1) is an endothelial cell-specific orphan receptor that plays a critical role in angiogenesis and vascular remodeling. It is involved in the modulation of angiopoietin function and is essential for the agonist activity of angiopoietin 1 (ANG1) and autocrine angiopoietin 2 (ANG2). Tie1 interacts with Tie2, and this interaction is modulated by integrin α5β1, which is crucial for the signaling pathways that control vascular stability and inflammation. It has been shown to localize with Tie2 at the cell surface and within the endothelial junctions, playing a role in the subcellular localization dynamics of the Ang-Tie signaling pathway. It also has been implicated in atherosclerosis, tumorigenesis, and inflammatory vascular remodeling.
参考文献:
1.Korhonen EA. et al. (2016). J Clin Invest. 126(9):3495-3510. 2.Zhang Y. et al. (2021). NPJ Syst Biol Appl. 7(1):34. 3.Seegar TC. et al. (2010). Mol Cell. 37(5):643-655. 4.D'Amico G. et al. (2014). J Clin Invest. 124(2):824-834.
