Recombinant Human ROR1 protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human ROR1 protein Gln30-Glu403 (Accession# Q01973-1) with a His tag at the C-terminus. |
| 基因ID | 4919 |
| 蛋白编号 | Q01973-1 |
| 预测分子量 | 43.1 kDa |
| SDS-PAGE | 50-65 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ROR1 is a member of the RTK family of orphan receptors related to muscle-specific kinase and Trk neurotrophin receptors. ROR1 is primarily expressed by neural crest cells during embryogenesis. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition. The human ROR1 gene encodes a 937 amino acid protein with an Ig-like domain, a cysteine-rich domain, a kringle domain, a tyrosine kinase domain, and a proline-rich domain.
参考文献:
1. P Masiakowski, et al. (1992) J Biol Chem. 267(36):26181-90. 2. Amir H Daneshmanesh, et al. (2008) Int J Cancer. 123(5):1190-5. 3. Nicholas Borcherding, et al. (2014) Protein Cell. 5(7):496-502. 4. Hyeyoon Chang, et al. (2015) Ann Diagn Pathol. 19(5):330-4.
