Recombinant Human Kallikrein 10 protein (mFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Kallikrein 10 protein Ala31-Asn276 (Accession# O43240) with a mouse IgG Fc tag at the N-terminus. |
| 基因ID | 5655 |
| 蛋白编号 | O43240 |
| 预测分子量 | 54.7 kDa |
| SDS-PAGE | 53-65 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
KLK10 is a secreted serine protease that is involved in various physiological processes and has potential as a diagnostic biomarker for ovarian cancer. Its expression is regulated by steroid hormones and is downregulated in testicular germ cell tumors and upregulated in ovarian cancer. KLK10 is expressed in various tissues, including the esophagus, skin, and others. It is particularly biased in the esophagus, skin, and other tissues. it is predicted to be secreted and is found in the extracellular space. Serum hK10, in combination with CA125, can improve the diagnostic sensitivity and specificity for ovarian cancer. KLK10 expression is decreased in human coronary arteries with advanced atherosclerotic plaques. KLK10 inhibits endothelial inflammation and protects the permeability barrier, ultimately reducing atherosclerosis. It is also a potential biomarker for ovarian cancer.
参考文献:
1. Kato K, Noda T, et al. (2024) Cancer Sci. 115(5):1520-1535. 2. Zhang M, Jiang L, et al. (2024) Heliyon. 10(1):e24287. 3. Williams D, Mahmoud M, et al. (2022) Elife. 11:e72579. 4. Cheng W, Song Q, et al. (2024) Tob Induc Dis. 22.
