Recombinant Human IBSP protein (His Tag)
种属
Human
纯度
>85 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >85 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IBSP protein Phe17-Gln317 (Accession# P21815) with a His tag at the C-terminus. |
| 基因ID | 3381 |
| 蛋白编号 | P21815 |
| 预测分子量 | 34.6 kDa |
| SDS-PAGE | 60-90 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Integrin-binding sialoprotein (IBSP), also known as Bone sialoprotein 2 (BSP2), is a glycoprotein that is mainly expressed in bone tissue. IBSP participates the coding of bone matrix and has a large influence on the formation, update, and repair of bones. High levels of IBSP have been found in various types of cancer, including colorectal cancer breast, esophageal squamous cell carcinoma. IBSP plays a significant role in tumor growth, invasion, and metastasis by promoting angiogenesis, cell migration and adhesion, and immune micro environment.
参考文献:
1.Chen Y. et al. (2021) Cancer Med. 10(12):4030-4045. 2.Pan B. et al. (2023) Front Immunol. 14:1188256. 3.Ma Y. et al. (2023) Aging (Albany NY). 16(1):28-42. 4.Ding W. et al. (2024) Cancer Rep (Hoboken). 7(8):e2153.
