Recombinant Human GLP1R protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human GLP1R protein Arg24-Glu139 (Accession# P43220) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 2740 |
| 蛋白编号 | P43220 |
| 预测分子量 | 39.1 kDa |
| SDS-PAGE | 45-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
GLP1R (glucagon-like peptide-1 receptor) is a G protein-coupled receptor belonging to the secretin receptor super-family, also known as class B. GLP1R is widely distributed in pancreatic islets, muscles, gastrointestinal tract, lung, liver, pancreas, and other tissues or organs. Moreover, GLP1R agonist has been reported to induce autophagy of endometrial carcinoma cells, and high GLP1R expression may be associated with good prognosis of endometrial carcinoma patients, suggesting that GLP1R is likely to participate in the progression of endometrial carcinoma.
参考文献:
1. Ranka Kanda, et al. (2018) BMC Cancer. 18(1):657. 2. Julia Ast, et al. (2021) EBioMedicine. 74:103739. 3. Wu Li, et al. (2022) J Clin Lab Anal. 36(10):e24604.
