Recombinant Human FGFRL1 protein (Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human FGFRL1 protein Ala25-Pro378 (Accession# Q8N441) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 53834 |
| 蛋白编号 | Q8N441 |
| 预测分子量 | 43.9 kDa |
| SDS-PAGE | 60-75 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Fibroblast growth factor receptor-like 1 (FGFRL1) is a member of the FGFR family. It is a type I transmembrane protein which contains three extracellular Ig-like modules, a transmembrane segment, and a short intracellular tail with a peculiar histidine-rich motif. It lacks the intracellular protein tyrosine kinase domain required for signal transduction by transphosphorylation. FGFRL1 binds to FGF ligands and heparin with high affinity. It exerts a negative effect on cell proliferation, but a positive effect on cell adhesion and cell differentiation.
参考文献:
1. M Wiedemann, et al. (2000) Genomics. 69(2):275-9. 2. Beat Trueb, et al. (2003) J Biol Chem. 278(36):33857-65. 3. Beat Trueb. (2011) Cell Mol Life Sci. 68(6):951-64. 4. Xiaochen Yang, et al. (2016) Int J Mol Med. 38(1):30-8.
