Recombinant Human CLEC4D protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CLEC4D protein Gly52-Asn215 (Accession# Q8WXI8) with a His tag at the N-terminus. |
| 基因ID | 338339 |
| 蛋白编号 | Q8WXI8 |
| 预测分子量 | 20.2 kDa |
| SDS-PAGE | 23-26 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CLEC4D, also called macrophage C‐type lectin (MCL), Dectin‐3, CLEC6, CLECSF8, is a member of the Dectin‐2 cluster of CTLRs, which also includes the related receptors Mincle and Dectin‐2. CLECSF8 is primarily expressed by peripheral blood neutrophils and monocytes and weakly by several subsets of peripheral blood dendritic cells. CLECSF8 can associate with FcRγ chain to trigger intracellular signaling, inducing phagocytosis, the respiratory burst, and the release of proinflammatory cytokines.
参考文献:
1. Kerscher B. et al. (2016). Eur J Immunol. 46(2):381-9. 2. Graham LM. et al. (2012). J Biol Chem. 287(31):25964-74. 3. Miyake Y. et al. (2013). Immunity. 38(5):1050-62. 4. Wilson GJ. et al. (2015). Cell Host Microbe. 17(2):252-9.
