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Recombinant Human CLEC3B protein (mFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

mFc Tag

生物活性

未测试

Cat no : Eg3608

Print datasheet

Synonyms

C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein, Tetranectin, TN, TNA

验证数据展示

  • Purity of Recombinant Human CLEC3B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CLEC3B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human CLEC3B was greater than 90% as determined by SEC-HPLC.

    The purity of Human CLEC3B was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human CLEC3B protein Glu22-Vla202 (Accession# P05452) with a mouse IgG Fc tag at the C-terminus.
基因ID 7123
蛋白编号 P05452
预测分子量 46.8 kDa
SDS-PAGE 44-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

C-Type Lectin Domain Family 3 Member B (CLEC3B) is a transmembrane Ca2+-binding protein, located in cell plasma, extracellular matrix, and exosomes. CLEC3B functions in the mineralization process in osteogenesis and neuroprotection and is associated with tumor invasion and metastasis via plasminogen activation, leading to extracellular proteolysis. Downregulation of CLEC3B has been reported in various diseases such as hepatocellular carcinoma, ovarian cancer, oral squamous cell carcinoma, and many other cancers. It was demonstrated in CLEC3B-deficient mice that the absence of CLEC3B impeded the mineralization process in osteogenesis.

参考文献:

1.Dai W. et al. (2019). Cell Commun Signal. 17(1):113. 
2.Xie XW. et al. (2021). Front Mol Biosci. 7:614034.
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