Recombinant Human Cadherin-17 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Cadherin-17 protein Gln23-Met787 (Accession# Q12864) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1015 |
| 蛋白编号 | Q12864 |
| 预测分子量 | 111.0 kDa |
| SDS-PAGE | 110-140 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Cadherin-17 (CDH17), also known as Liver-Intestine cadherin (LI-cadherin), is a member of the cadherin superfamily. Cadherin-17 is expressed in various tissues, including the intestine and liver, and plays a role in cell adhesion, proliferation, and migration in colorectal cancer (CRC) metastasis. It binds and activates α2β1 integrin, promoting cell adhesion and proliferation. High expression of Cadherin-17 is significantly associated with liver metastasis and poor survival in patients with colorectal cancer.
参考文献:
1.Bartolomé RA. et al. (2024). J Exp Clin Cancer Res. 43(1):31. 2.Bartolomé RA. et al. (2014). Oncogene. 33(13):1658-1669.
