Recombinant Human CD117/c-kit protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD117 protein Gln26-Thr516 (Accession# P10721-2) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3815 |
| 蛋白编号 | P10721-2 |
| 预测分子量 | 81.5 kDa |
| SDS-PAGE | 85-125 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit. It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3. CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal). CD117 plays an important role in early hemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous syste.
参考文献:
1. Y Yarden, et al. (1987). EMBO J. 6(11):3341-51. 2. Brittni M Foster, et al. (2018). Biomedicines. 6(1):31. 3. L K Ashman, et al. (1999). Int J Biochem Cell Biol. 31(10):1037-51. 4. Johan Lennartsson, et al. (2012). Physiol Rev. 92(4):1619-49.
