Recombinant Canine IL-6 protein (rFc Tag)
种属
Canine
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Canine IL-6 protein Phe21-Met207 (Accession# P41323) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 403985 |
| 蛋白编号 | P41323 |
| 预测分子量 | 48.1 kDa |
| SDS-PAGE | 48-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Interleukin-6 (IL-6) is an interleukin that acts as both a pro- and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types, including T cells and macrophages, as a phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the terminal differentiation of B cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces the growth of myeloma and plasmacytoma and the differentiation of neurons and acts on B cells, T cells, hepatocytes, haematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced by muscle that is increased in response to muscle contraction. IL-6 has been shown to interact with the interleukin-6 receptor and glycoprotein 130. In addition, IL-6 has been implicated in haematopoiesis, bone metabolism and cancer progression, and has been defined as essential in directing the transition from innate to acquired immunity.
参考文献:
1.Aliyu M. et al. (2022) Int Immunopharmacol. 111:109130. 2.Grebenciucova E. et al. (2023) Front Immunol. 14:1255533. 3.Tanaka T. et al. (2016) Adv Exp Med Biol. 941:79-88.
