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验证数据展示

  • WB analysis of HeLa using 32874-1-AP (same clone as 32874-1-PBS)

    WB analysis of HeLa using 32874-1-AP (same clone as 32874-1-PBS)

    WB result of TXNDC15 antibody (32874-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TXNDC15 transfected HeLa cells. This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

  • WB analysis using 32874-1-AP (same clone as 32874-1-PBS)

    WB analysis using 32874-1-AP (same clone as 32874-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32874-1-AP (TXNDC15 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary cancer using 32874-1-AP (same clone as 32874-1-PBS)

    IHC staining of human ovary cancer using 32874-1-AP (same clone as 32874-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 32874-1-AP (TXNDC15 antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

TXNDC15 Polyclonal antibody, PBS Only

TXNDC15 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 32874-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

C5orf14, Thioredoxin Domain Containing 15, Thioredoxin domain-containing protein 15, UNQ335/PRO534

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

32874-1-PBS targets TXNDC15 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag37138

Product name: Recombinant human TXNDC15 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 33-321 aa of BC032568

Sequence: VEVAEESGRLWSEEQPAHPLQVGAVYLGEEELLHDPMGQDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGVTCGAGGAEDSRCNVRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 thioredoxin domain containing 15
别名 C5orf14, Thioredoxin Domain Containing 15, Thioredoxin domain-containing protein 15, UNQ335/PRO534
观测分子量55 kDa
GenBank蛋白编号BC032568
基因名称 TXNDC15
Gene ID (NCBI) 79770
RRIDAB_3742773
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ96J42
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TXNDC15 (thioredoxin domain-containing protein 15) is a single-pass type I transmembrane protein that contains a thioredoxin domain and is primarily localized in the cytoplasm. It plays a positive regulatory role in the Hedgehog signaling pathway within cilia and actively participates in the process of ciliogenesis, exerting significant influence on the structure and function of cilia-an essential cellular organelle. Additionally, TXNDC15 has been found to form mixed disulfide complexes with endoplasmic reticulum-resident protein disulfide isomerase (PDI) family members, such as ERp57, PDI, and ERp44, suggesting its involvement in protein folding and quality control processes. Notably, mutations in the TXNDC15 gene are associated with a rare and lethal genetic disorder known as Meckel-Gruber syndrome, which is caused by defects in ciliogenesis.

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