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验证数据展示

  • WB analysis using 30031-1-AP (same clone as 30031-1-PBS)

    WB analysis using 30031-1-AP (same clone as 30031-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30031-1-AP (SLC43A2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30031-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 30031-1-AP (same clone as 30031-1-PBS)

    IHC staining of human placenta using 30031-1-AP (same clone as 30031-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 30031-1-AP (SLC43A2 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30031-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SLC43A2 antibody included
  • IHC staining of human placenta using 30031-1-AP (same clone as 30031-1-PBS)

    IHC staining of human placenta using 30031-1-AP (same clone as 30031-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 30031-1-AP (SLC43A2 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30031-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SLC43A2 antibody included
  • FC experiment of Jurkat using 30031-1-AP (same clone as 30031-1-PBS)

    FC experiment of Jurkat using 30031-1-AP (same clone as 30031-1-PBS)

    1x10^6 Jurkat cells were intracellularly stained with 0.25 ug SLC43A2 Polyclonal antibody (30031-1-AP) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Isotype Control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00017). This data was developed using the same antibody clone with 30031-1-PBS in a different storage buffer formulation.

  • WB analysis using 30031-1-AP (same clone as 30031-1-PBS)

    WB analysis using 30031-1-AP (same clone as 30031-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30031-1-AP (SLC43A2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30031-1-PBS in a different storage buffer formulation.

  • IF Staining of human lung cancer using 30031-1-AP (same clone as 30031-1-PBS)

    IF Staining of human lung cancer using 30031-1-AP (same clone as 30031-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human lung cancer tissue using SLC43A2 antibody (30031-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30031-1-PBS in a different storage buffer formulation.

SLC43A2 Polyclonal antibody, PBS Only

SLC43A2 Polyclonal Antibody for WB, IHC, IF-P, FC (Intra), Indirect ELISA
Cat No. 30031-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF-P, FC (Intra), Indirect ELISA

别名

LAT4, L-type amino acid transporter 4, PP7664

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SLC43A2 Ready-To-Use IHC Kit. SLC43A2 primary antibody included.

产品信息

30031-1-PBS targets SLC43A2 in WB, IHC, IF-P, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF-P, FC (Intra), Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag31341

Product name: Recombinant human SLC43A2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 516-569 aa of BC027923

Sequence: WVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 solute carrier family 43, member 2
别名 LAT4, L-type amino acid transporter 4, PP7664
计算分子量 63 kDa
观测分子量 48-53 kDa
GenBank蛋白编号BC027923
基因名称 SLC43A2
Gene ID (NCBI) 124935
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8N370
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SLC43A2 (solute carrier family 43 member 2, also known as LAT4) is a multi-pass transmembrane protein that mediates sodium- and chloride-independent uptake of large neutral amino acids, including methionine, leucine and phenylalanine. Highly expressed in kidney, placenta and liver, it supplies essential amino acids to support fetal growth, protein synthesis and one-carbon metabolism. Over-expressed in head-and-neck, liver and other cancers, SLC43A2-driven methionine influx maintains methylation reactions and YAP activity, promoting tumor proliferation and chemo-resistance . Pharmacological inhibition of SLC43A2 sensitizes tumors to therapy, highlighting its potential as a metabolic target. (PMID: 39747898; 15659399; 30379325)

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