验证数据展示
产品信息
87619-1-PBS targets Phospho-MSK1 (Ser376) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
| 别名 | MSK1 (phospho S376), MSK1 (Ser376), phospho MSK1, Phospho-MSK1, Phospho-MSK1(S376) |
| 计算分子量 | 549aa,62 kDa; 802aa,90 kDa |
| 观测分子量 | 90 kDa |
| GenBank蛋白编号 | BC017187 |
| 基因名称 | MSK1 |
| Gene ID (NCBI) | 9252 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O75582 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Mitogen- and stress-activated kinase 1 (MSK1) is a protein kinase that plays a crucial role in the regulation of gene expression in response to various stimuli, including mitogens, stress, and inflammatory signals. ERK1/2 or p38 MAPK activate MSK1 by phosphorylating Thr581 and Ser360; this primes the C-terminal domain, which then autophosphorylates Ser376 (and Ser212) to unlock the N-terminal catalytic site. (PMID: 15568999)
