VDR Monoclonal antibody
VDR Monoclonal Antibody for ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
ELISA
Conjugate
Unconjugated
CloneNo.
4C2F1
验证数据展示
产品信息
60116-2-Ig targets VDR in ELISA applications and shows reactivity with human samples.
| Tested Applications | ELISA |
| Tested Reactivity | human |
| Immunogen | VDR fusion protein Ag6012 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | vitamin D (1,25- dihydroxyvitamin D3) receptor |
| Synonyms | |
| Calculated Molecular Weight | 48 kDa |
| Observed Molecular Weight | 55 kDa |
| GenBank Accession Number | BC060832 |
| Gene Symbol | VDR |
| Gene ID (NCBI) | 7421 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P11473 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The vitamin D receptor (VDR), also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. This antibody is a mouse monoclonal IgG2a antibody to human VDR.