验证数据展示
产品信息
98582-1-PBS targets TNFSF12 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Eg2870 Product name: Recombinant Human TNFSF12 protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 93-249 aa of NM_003809.2 Sequence: RSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | tumor necrosis factor (ligand) superfamily, member 12 |
| 别名 | CD255, DR3LG, hCG_1991317, HCG1991317, isoform CRA_b TWEAK Tumor necrosis factor, Ligand |
| 计算分子量 | 27 kDa |
| GenBank蛋白编号 | NM_003809.2 |
| 基因名称 | TNFSF12 |
| Gene ID (NCBI) | 8742 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O43508-1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TNFSF12, also known as TWEAK (TNF-like weak inducer of apoptosis), is a member of the tumor necrosis factor ligand superfamily. It functions as a cytokine by binding to its primary receptor, Fn14 (TNFRSF12A), and plays diverse roles in immune regulation, angiogenesis, tissue repair, and inflammation (PMID: 39905000). TNFSF12 is upregulated in multiple solid tumors and promotes cancer cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) (PMID: 28639899).
