验证数据展示
产品信息
87509-1-PBS targets TCR α/β in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, IHC, Indirect ELISA Application Description |
| 经测试反应性 | human, rat |
| 免疫原 |
CatNo: Eg9184 Product name: Recombinant human TCR α/β protein Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS Tag: C-6*HIS Sequence: TRAC IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLS 1-115 TRBC DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSA 1-144 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | TCR α/β |
| 别名 | |
| 观测分子量 | 35 kDa |
| 基因名称 | |
| Gene ID (NCBI) | |
| RRID | AB_3745590 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TCR α/β (T-cell receptor α/β heterodimer) is a core molecule of the adaptive immune system, formed by the disulfide bond linkage of α and β transmembrane polypeptide chains. It is present on the surface of most mature T cells and non-covalently associates with the CD3 complex to form the complete T-cell receptor (TCR-CD3 complex). Its primary function is to recognize antigen peptides presented by major histocompatibility complex (MHC) molecules. The genes encoding TCR α/β undergo V(D)J recombination, generating an extraordinarily high degree of diversity, enabling the immune system to recognize a vast array of antigens. TCR α/β plays a decisive role in T-cell development, activation, clonal selection, and immune responses, making it a fundamental target in immunology research and a key molecule in tumor immunotherapy, such as TCR-T therapy.
