验证数据展示
产品信息
68344-1-PBS targets SMNDC1 in Indirect ELISA, WB applications and shows reactivity with human samples.
| 经测试应用 | Indirect ELISA, WB Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag33140 Product name: Recombinant human SMNDC1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-238 aa of BC011234 Sequence: MSEDLAKQLASYKAQLQQVEAALSGNGENEDLLKLKKDLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | survival motor neuron domain containing 1 |
| 别名 | Survival motor neuron domain-containing protein 1, SPF30, SMN-related protein, SMNR, SMN related protein |
| 计算分子量 | 238 aa, 27 kDa |
| 观测分子量 | 32 kDa |
| GenBank蛋白编号 | BC011234 |
| 基因名称 | SMNDC1 |
| Gene ID (NCBI) | 10285 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | O75940 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Survival motor neuron domain-containing protein 1 (SMNDC1), also known as survival of motor neuron-related-splicing factor 30 (SPF30) or SMN-related protein (SMNR), is a constituent of the spliceosome complex that plays an essential role in spliceosome assembly by recruiting U4/U5/U6 tri-snRNP to the pre-spliceosomal complex (PMID: 9817934; 11331595; 30904945). Both SMNDC1 and SMN1 contain a highly conserved central Tudor domain which functions as a protein-protein interaction surface and mediates binding to the spliceosomal Sm proteins (PMID: 11331595).
