Recombinant Rat gp130/IL6ST protein (His Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat gp130/IL6ST protein Gln23-Glu618 (Accession# H9BFG4) with a His tag at the C-terminus. |
| 基因ID | 25205 |
| 蛋白编号 | H9BFG4 |
| 预测分子量 | 68.0 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
GP130, also known as IL6ST, is a transmembrane protein that serves as a shared signal-transducing subunit for a variety of cytokines, including interleukin-6 (IL-6), IL-11, IL-27, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC)/CLC factor 1 (CLCF-1), and neuropoietin. This protein is highly conserved among vertebrates and plays a crucial role in mediating interactions between a wide range of immune and non-immune cells. GP130 was originally discovered in 1978 and was successfully cloned and expressed in 1990, leading to a deeper understanding of cytokine signaling pathways.
参考文献:
1. Osman, Essam Eldin A, and Nouri Neamati. Pharmacological reviews vol. 76,6 (2024): 1399-1443. 2. Xu, Shili, and Nouri Neamati. Expert opinion on therapeutic targets vol. 17,11 (2013): 1303-28. 3. Andersson, L C et al. Proceedings of the National Academy of Sciences of the United States of America vol. 75,7 (1978): 3455-8.