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验证数据展示

  • WB analysis using 11882-1-AP (same clone as 11882-1-PBS)

    WB analysis using 11882-1-AP (same clone as 11882-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11882-1-AP (RBBP6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11882-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 11882-1-AP (same clone as 11882-1-PBS)

    IHC staining of human placenta using 11882-1-AP (same clone as 11882-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11882-1-AP (RBBP6 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11882-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with RBBP6 antibody included
  • IHC staining of human rectal cancer using 11882-1-AP (same clone as 11882-1-PBS)

    IHC staining of human rectal cancer using 11882-1-AP (same clone as 11882-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human rectal cancer tissue slide using 11882-1-AP (RBBP6 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11882-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with RBBP6 antibody included
  • IHC staining of mouse kidney using 11882-1-AP (same clone as 11882-1-PBS)

    IHC staining of mouse kidney using 11882-1-AP (same clone as 11882-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 11882-1-AP (RBBP6 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11882-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with RBBP6 antibody included
  • Featured Product
  • KD/KO验证

RBBP6 Polyclonal antibody, PBS Only

RBBP6 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 11882-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

E3 ubiquitin-protein ligase RBBP6, EC:2.3.2.27, MY038, P2P R, P2PR

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy RBBP6 Ready-To-Use IHC Kit. RBBP6 primary antibody included.

产品信息

11882-1-PBS targets RBBP6 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag2484

Product name: Recombinant human RBBP6 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-118 aa of BC029352

Sequence: MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAVCKNTISHFFYTLLLPL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 retinoblastoma binding protein 6
别名 E3 ubiquitin-protein ligase RBBP6, EC:2.3.2.27, MY038, P2P R, P2PR
计算分子量 1792 aa, 200 kDa
观测分子量250 kDa
GenBank蛋白编号BC029352
基因名称 RBBP6
Gene ID (NCBI) 5930
RRIDAB_2177794
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ7Z6E9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RBBP6 (retinoblastoma binding protein 6) is a multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase due to the presence of a RING finger domain [PMID:18851979]. RBBP6 contains an N-terminal ubiquitin-like domain and a cysteine-rich RING finger-like domain, through which it promotes the ubiquitination of p53 by Hdm2 in an E4-like manner [PMID:17470788]. It is implicated in a diverse set of cellular functions, including mRNA metabolism, regulation of the cell cycle, tumorigenesis, and development [PMID:12938151,17470788].

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