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2-Bromo-4'-hydroxyacetophenone

CAS号

2491-38-5

分子式

C8H7BrO2

主要靶点

Phosphatase

仅限科研使用

Cat No : CM01356

Print datasheet

Synonyms

a-Bromo-4-hydroxyacetophenone|alpha-Bromo-4-hydroxyacetophenone|4-Hydroxyphenacyl Bromide|4-Hydroxyphenacyl bromide|2 Bromo 4' hydroxyacetophenone|2-溴-4'-羟基苯乙酮|2-Bromo-4'-hydroxyacetophenone|2Bromo4'hydroxyacetophenone|SHP-1 Inhibitor II|α-Bromo-4-hydroxyacetophenone|Inhibitor|inhibit|Phosphatase|protein tyrosine phosphatase(PTP)|PTP Inhibitor I

验证数据展示

  • CAS No.: 2491-38-5

    2-Bromo-4'-hydroxyacetophenone
    CAS#: 2491-38-5

产品信息

CAS号 2491-38-5
分子式 C8H7BrO2
主要靶点 Phosphatase
主要通路 代谢
分子量 215.04
纯度 99.07%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 a-Bromo-4-hydroxyacetophenone|alpha-Bromo-4-hydroxyacetophenone|4-Hydroxyphenacyl Bromide|4-Hydroxyphenacyl bromide|2 Bromo 4' hydroxyacetophenone|2-溴-4'-羟基苯乙酮|2-Bromo-4'-hydroxyacetophenone|2Bromo4'hydroxyacetophenone|SHP-1 Inhibitor II|α-Bromo-4-hydroxyacetophenone|Inhibitor|inhibit|Phosphatase|protein tyrosine phosphatase(PTP)|PTP Inhibitor I

靶点活性

SHP1:43 μM (Ki, cell free)|PTP1B:42 μM (Ki, cell free)

溶解度

DMSO:60 mg/mL (279.02 mM);H2O:Insoluble;Ethanol:20 mg/mL (93.01 mM)

细胞实验

Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis.

参考文献

1.Arabaci, G., et al. αHaloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. Journal of the American Chemical Society 121(21), 5085-5086 (1999).
2.Heneberg, P. Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. Current Medicinal Chemistry 16(6), 706-733 (2009).
3.Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA[J]. Journal for immunotherapy of cancer. 2020, 8(2).

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