验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IHC | See 2 publications below |
产品信息
10859-1-AP targets PMS1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human |
| 免疫原 |
CatNo: Ag1158 Product name: Recombinant human PMS1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-166 aa of BC008410 Sequence: MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGKKVALYTNILYLFCLNCWFKKKKVTR 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) |
| 别名 | HNPCC3, hPMS1, PMS1, PMS1 protein homolog 1, PMSL1 |
| 计算分子量 | 106 kDa |
| GenBank蛋白编号 | BC008410 |
| 基因名称 | PMS1 |
| Gene ID (NCBI) | 5378 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P54277 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The multiple eukaryotic homologs of the bacterial MutL mismatch repair protein are implicated along with MutS homologs in maintaining genomic integrity during DNA replication and recombination [PMID:16612326]. DNA mismatch repair (MMR) corrects replication errors that would otherwise lead to mutations and, potentially, various forms of cancer. Among several proteins required for eukaryotic MMR, MutLα is a heterodimer comprised of Mlh1 and PMS1 [PMID:19115045]. PMS1 contains an N-terminal domain (NTD) and C-terminal domain (CTD) ,which separated by a flexible linker. Dimerization occurs between the CTDs and the CTD of PMS1 houses a strand-specific endonuclease that is necessary for MMR [PMID:17951253].
发表文章
| Species | Application | Title |
|---|---|---|
Breast Cancer Res Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families. | ||