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验证数据展示

  • WB analysis using 18263-1-AP (same clone as 18263-1-PBS)

    WB analysis using 18263-1-AP (same clone as 18263-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18263-1-AP (PHLDA1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18263-1-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 18263-1-AP (same clone as 18263-1-PBS)

    IHC staining of human skin cancer using 18263-1-AP (same clone as 18263-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 18263-1-AP (PHLDA1 antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18263-1-PBS in a different storage buffer formulation.

  • IF Staining of A375 using 18263-1-AP (same clone as 18263-1-PBS)

    IF Staining of A375 using 18263-1-AP (same clone as 18263-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A375 cells using PHLDA1 antibody (18263-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18263-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

PHLDA1 Polyclonal antibody, PBS Only

PHLDA1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 18263-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

Apoptosis-associated nuclear protein, DT1P1B11, PHRIP, Pleckstrin homology-like domain family A member 1, PQ-rich protein

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

18263-1-PBS targets PHLDA1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag13125

Product name: Recombinant human PHLDA1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-259 aa of BC018929

Sequence: MLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQHQQQQQQQQQQQQQQPGQGPAEPSQPSGPAVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHRLLRSTSNSA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 pleckstrin homology-like domain, family A, member 1
别名 Apoptosis-associated nuclear protein, DT1P1B11, PHRIP, Pleckstrin homology-like domain family A member 1, PQ-rich protein
计算分子量 45 kDa
观测分子量 40-45 kDa
GenBank蛋白编号BC018929
基因名称 PHLDA1
Gene ID (NCBI) 22822
RRIDAB_2163284
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8WV24
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PHLDA1, also known as PHRIP and TDAG51, is a multifunctional protein involved in various biological processes. It can induce apoptosis in various cell types, including T cells, hippocampal cells, endothelial cells, melanoma cells, and mouse embryonic fibroblasts(PMID: 30207029). PHLDA1 plays a role in inhibiting growth factor signaling and has been implicated in tumor suppression through its ability to repress Akt activity by binding to phosphatidylinositol (PIP) lipids(PMID: 36142223).

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