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NSC 66811

NSC 66811 是一种MDM2-p53抑制剂，其结合到 MDM2 的Ki 值为 120 nM。

CAS号

6964-62-1

分子式

C23H20N2O

主要靶点

Mdm2

仅限科研使用

Cat No : CM05037

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Synonyms

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  • CAS No.: 6964-62-1

    NSC 66811
    CAS#: 6964-62-1

产品信息

NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.

CAS号 6964-62-1
分子式 C23H20N2O
主要靶点 Mdm2
主要通路 凋亡
分子量 340.42
纯度 96.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

p53-MDM2:120 nM (ki)

体外活性

Due to the functional activation of p53, NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf.

溶解度

DMSO:99 mg/mL (290.81 mM)

参考文献

1.Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62.

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