NSC 66811

CAS号

6964-62-1

分子式

C23H20N2O

主要靶点

Mdm2

仅限科研使用

Cat No : CM05037

Print datasheet

Synonyms

p53|p53-MDM2|NSC66811|NSC-66811|NSC 66811|inhibit|Inhibitor|MDM2|MDM-2/p53|HCT-116



产品信息

CAS号 6964-62-1
分子式 C23H20N2O
主要靶点 Mdm2
主要通路 凋亡
分子量 340.42
纯度 96.94%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 p53|p53-MDM2|NSC66811|NSC-66811|NSC 66811|inhibit|Inhibitor|MDM2|MDM-2/p53|HCT-116

靶点活性

p53-MDM2:120 nM (ki)

体外活性

由于p53的功能激活,NSC 66811(0, 5, 10, 20 μM)剂量依赖性地诱导p53、MDM2和p21cip1/waf的累积。

溶解度

DMSO:99 mg/mL (290.81 mM)

参考文献

1.Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2