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验证数据展示

  • Single Cell Sequencing experiment G81042-1-5C on Resting PBMC

    Single Cell Sequencing experiment G81042-1-5C on Resting PBMC

    G81042-1-5C was used to stain Resting PBMC and analyzed with 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing kit with Fix-Stain protocol.

  • Single Cell Sequencing experiment G81042-1-5C on PBMC treated with 4hr LPS + TI

    Single Cell Sequencing experiment G81042-1-5C on PBMC treated with 4hr LPS + TI

    G81042-1-5C was used to stain PBMC under 4hr LPS + TI treatment and analyzed with 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing kit with Fix-Stain protocol.

MultiPro® 5CFLX Anti-Human Lamin A/C (5I16)

Lamin A/C Recombinant Antibody for Single Cell (Intra)
Cat No. G81042-1-5C

产品说明书

CloneNo. 5I16

宿主/亚型

Rabbit / IgG

种属反应性

Human

应用

Single Cell (Intra)

别名

70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, lamin A, lamin A/C, LDP1, LFP, LGMD1B, LMN1, LMNA, LMNC, Prelamin A/C, PRO1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  {{ptg:cur_Conjugation}}
规格: 

-/ -

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经过测试的应用

Positive Single Cell (Intra) detected in10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product.
Planning an IHC experiment? We recommend our IHCeasy Lamin A/C Ready-To-Use IHC Kit. Lamin A/C primary antibody included.

推荐稀释比

应用推荐稀释比
SINGLE CELL (INTRA)<0.5ug/test
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

产品信息

G81042-1-5C targets Lamin A/C in Single Cell (Intra) applications and shows reactivity with Human samples.

经测试应用 Single Cell (Intra) Application Description
经测试反应性 Human
免疫原 Lamin A/C fusion protein Ag0408 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Oligo Conjugate
产品类型 Recombinant
全称 MultiPro® 5CFLX Anti-Human Lamin A/C (5I16)
别名 70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, lamin A, lamin A/C, LDP1, LFP, LGMD1B, LMN1, LMNA, LMNC, Prelamin A/C, PRO1
计算分子量 65 kDa
GenBank蛋白编号BC003162
基因名称 Lamin A/C
Gene ID (NCBI) 4000
ENSEMBL Gene IDENSG00000160789
RRIDAB_3673977
偶联类型 5CFLX
完整寡核苷酸序列CGGAGATGTGTATAAGAGACAGAAGTGGAGTGTGTCTCCCATATAAGAAA
条形码序列AAGTGGAGTGTGTCT
形式 Liquid
UNIPROT IDP02545
储存缓冲液 PBS with 1mM EDTA and 0.09% sodium azide , pH 7.3
储存条件2-8°C Stable for one year after shipment.

背景介绍

Lamin A/C is also named as LMNA, or LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation (PMID: 16179429). Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa, 65 kDa, 70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C.

Protocols

Our current MultiPro staining protocol for the cocktailDownload protocol
10x Genomics CG000149_Demonstrated Protocol CellSurface Protein Labeling_Rev D.pdfDownload protocol