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验证数据展示

  • WB analysis of HepG2 using 24893-1-AP (same clone as 24893-1-PBS)

    WB analysis of HepG2 using 24893-1-AP (same clone as 24893-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 24893-1-AP (MRP2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

  • IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

    IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 24893-1-AP (MRP2 antibody at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

  • IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

    IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 24893-1-AP (MRP2 antibody at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

MRP2 Polyclonal antibody, PBS Only

MRP2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 24893-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

ABCC2, ABCC 2, ATP-binding cassette sub-family C member 2, CMOAT, CMOAT1

缓冲液配方: 
偶联物:  Unconjugated
规格价格库存

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产品信息

24893-1-PBS targets MRP2 in applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag18694

Product name: Recombinant human ABCC2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 193-325 aa of BC136419

Sequence: NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
别名 ABCC2, ABCC 2, ATP-binding cassette sub-family C member 2, CMOAT, CMOAT1
计算分子量 1545 aa, 174 kDa
观测分子量 190-250 kDa
GenBank蛋白编号BC136419
基因名称 ABCC2
Gene ID (NCBI) 1244
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ92887
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation. (16434545, 18834541, 23045960)

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