Recombinant Human THPO protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human THPO protein Ser22-Gly353 (Accession# P40225-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 7066 |
| 蛋白编号 | P40225-1 |
| 预测分子量 | 61.0 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Thrombopoietin (TPO) is a primary regulator of megakaryocyte development and platelet production in mammals. Human TPO constitutively circulates and maintains thrombopoiesis through interaction with its cognate receptor, myeloproliferative leukemia protein(MPL). TPO also plays an important role in the maintenance and regulation of hematopoietic stem cells (HSCs). Germline mutations of THPO were reported as causes of hereditary thrombocythemia.
参考文献:
1. Kuter, David J. International journal of hematology vol. 98,1 (2013): 10-23. 2. Kimura, Hiroyuki et al. Experimental hematology vol. 134 (2024): 104208. 3. Kaushansky, K. Journal of thrombosis and haemostasis : JTH vol. 1,7 (2003): 1587-92. 4.Decker, Matthew et al. Science (New York, N.Y.) vol. 360,6384 (2018): 106-110.