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Species Reactivity
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Species Reactivity
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验证数据展示

  • IHC staining of mouse cerebellum using 21766-1-AP (same clone as 21766-1-PBS)

    IHC staining of mouse cerebellum using 21766-1-AP (same clone as 21766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21766-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse cerebellum using 21766-1-AP (same clone as 21766-1-PBS)

    IHC staining of mouse cerebellum using 21766-1-AP (same clone as 21766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21766-1-PBS in a different storage buffer formulation.

GABRA6 Polyclonal antibody, PBS Only

GABRA6 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 21766-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

21766-1-PBS targets GABRA6 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag16375

Product name: Recombinant human GABRA6 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 329-424 aa of BC096241

Sequence: NLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRIL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 gamma-aminobutyric acid (GABA) A receptor, alpha 6
别名
计算分子量 453 aa, 51 kDa
GenBank蛋白编号BC096241
基因名称 GABRA6
Gene ID (NCBI) 2559
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ16445
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. GABAA receptors are formed by pentameric assembly of 19 different subunit subtypes (α1-α6, β1-β3, γ1-γ3, δ, ɛ, π, θ and ρ1-ρ3) (PMID: 21930603). The mutation R46W of GABRA6 is associated with the pathogenesis of childhood absence epilepsy (CAE) (PMID: 21930603).