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验证数据展示

  • WB analysis of HeLa using 19254-1-AP (same clone as 19254-1-PBS)

    WB analysis of HeLa using 19254-1-AP (same clone as 19254-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 19254-1-AP (COSMC antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19254-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19254-1-AP (COSMC antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19254-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19254-1-AP (COSMC antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19254-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

COSMC Polyclonal antibody, PBS Only

COSMC Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 19254-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

19254-1-PBS targets COSMC in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag6899

Product name: Recombinant human C1GALT1C1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-318 aa of BC050441

Sequence: MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 C1GALT1-specific chaperone 1
别名
计算分子量 36 kDa
观测分子量 36-37 kDa
GenBank蛋白编号BC050441
基因名称 COSMC
Gene ID (NCBI) 29071
RRIDAB_10638003
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96EU7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

COSMC (C1GALT1C1) is a molecular chaperone required for expression of active T-synthase (CIGALT1) which catalyzes the synthesis of Tn antigen. Tn antigens are cancer-associated glycans and play an important role in tumor progression. Dysfunctional COSMC is able to convert a wild type protein into a tumor-specific antigen affecting tumor cell biology. COSMC overexpression had been observed in various cancers. COSMC mutations have been observed in an autoimmune disease Tn syndrome.

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