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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
0
Conjugate
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验证数据展示

  • WB analysis of HepG2 using 18029-1-AP (same clone as 18029-1-PBS)

    WB analysis of HepG2 using 18029-1-AP (same clone as 18029-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 18029-1-AP (CARD6 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18029-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 18029-1-AP (same clone as 18029-1-PBS)

    IHC staining of human testis using 18029-1-AP (same clone as 18029-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis using 18029-1-AP (CARD6 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18029-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 18029-1-AP (same clone as 18029-1-PBS)

    IHC staining of human testis using 18029-1-AP (same clone as 18029-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis using 18029-1-AP (CARD6 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18029-1-PBS in a different storage buffer formulation.

CARD6 Polyclonal antibody, PBS Only

CARD6 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 18029-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

18029-1-PBS targets CARD6 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 CARD6 fusion protein Ag12595 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 caspase recruitment domain family, member 6
别名
计算分子量 1037 aa, 116 kDa
观测分子量 130 kDa
GenBank蛋白编号BC093825
基因名称 CARD6
Gene ID (NCBI) 84674
RRIDAB_2290686
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BX69
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The caspase recruitment domain (CARD) is a homotypic protein-protein interaction module that links components of signal transduction pathways implicated in the regulation of apoptosis or adaptive or innate immunity. Although much progress has been made in assigning precise roles to most CARD-containing proteins, the functions of the 1,037-amino-acid (aa) human and 1,175-aa mouse CARD6 proteins are still unknown. CARD6 has a unique structure in that it contains the CARD at the N terminus, a glutamic acid-rich region following the CARD, and a proline-rich region at the C terminus. CARD6 also harbors a 350-aa region with similarity to upregulated gene 4 (URG4), a protein that is induced in response to hepatitis Bx antigen overexpression and exerts a positive effect on proliferation. Both CARD6 and URG4 share structural features with members of the multifaceted, IFN-inducible GTPase (IFNiGTPase) superfamily, which contains some of the proteins most abundantly induced during cell-autonomous immune responses. The calcualted molecular weight of CARD is 116 kDa, but modified CARD6 is about 130 kDa. (PMID: 18160713)