×
Use Able AI chat for product recommendations

BMS-191011

BMS-191011 (BMS-A) 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂，在中风模型中有研究价值。

CAS号

202821-81-6

分子式

C16H10ClF3N2O3

主要靶点

Potassium Channel

仅限科研使用

Cat No : CM06071

Print datasheet

Synonyms

BMS191011|BMS-191011|BMS-A|BMS 191011|IGR39|Inhibitor|KcsA|inhibit|neuroprotective activity|rodent models of stroke|Panc-1|PotassiumChannel|Potassium Channel

验证数据展示

  • CAS No.: 202821-81-6

    BMS-191011
    CAS#: 202821-81-6

产品信息

BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models

CAS号 202821-81-6
分子式 C16H10ClF3N2O3
主要靶点 Potassium Channel
主要通路 离子通道
分子量 370.71
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 BMS191011|BMS-191011|BMS-A|BMS 191011|IGR39|Inhibitor|KcsA|inhibit|neuroprotective activity|rodent models of stroke|Panc-1|PotassiumChannel|Potassium Channel

体内活性

在活体内，BMS 191011（10-100 μg/kg，静脉注射）能够增加大鼠视网膜动脉的直径，而不影响血压或心率，这一效果可被BKCa通道阻断剂iberiotoxin[1]逆转。

溶解度

DMSO:125 mg/mL (337.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.79 mM)

参考文献

1.Mori A , Suzuki S , Sakamoto K , et al. BMS-191011, an Opener of Large-Conductance Ca2+-Activated Potassium Channels, Dilates Rat Retinal Arterioles in Vivo[J]. Biological & Pharmaceutical Bulletin, 2011, 34(1):150-152.
2.Hewawasam P . Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13(10):1695-1698.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2
||
New chat

Able™

正在加载，请稍候...