ACVR1 Monoclonal antibody
ACVR1 Monoclonal Antibody for ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse
Applications
ELISA
Conjugate
Unconjugated
CloneNo.
2G1B1
验证数据展示
产品信息
60014-1-Ig targets ACVR1 in ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | ELISA |
Tested Reactivity | human, mouse |
Immunogen | ACVR1 fusion protein Ag1556 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | activin A receptor, type I |
Synonyms | activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, Activin Receptor Type IA, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI |
Calculated Molecular Weight | 509 aa, 57 kDa |
Observed Molecular Weight | 57 kDa |
GenBank Accession Number | BC033867 |
Gene Symbol | ACVR1 |
Gene ID (NCBI) | 90 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Caprylic acid/ammonium sulfate precipitation |
UNIPROT ID | Q04771 |
Storage Buffer | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).